Sunday, 18 December 2011

ETIOLOGY OF SOME SKIN DISORDERS


  • Pyoderma gangrenosum - It's often associated with inflammatory conditions, such as ulcerative colitis and Crohn's disease. If you have pyoderma gangrenosum, new skin trauma, such as a cut or puncture wound, may result in the formation of new ulcers. This tendency of new ulcers to form from trauma, including surgery, is known as pathergy. ulcerative colitis., rheumatoid arthritis, and multiple myeloma (MM) sufferes have the condition.



  • Erythema nodosum- Erythema nodosum may occur as an isolated condition or in association with other conditions. Conditions that are associated with erythema nodosum include medications (sulfa-related drugs,birth control pills, estrogen), strep throat,cat scratch disease, fungal diseases,infectious mononucleosis,sarcoidosis, behchet's disease, inflammatory bowel diseases (crohn's disease and ulcerative collitis), and normal pregnancy.

 Erythema nodosum is presumed to be a hypersensitivity reaction and may occur in association with several systemic diseases or drug therapies, or it may be idiopathic.



  • Ecthyma gangrenosum - Pseudomonas aeruginosa bacteremia. EG usually occurs in patients who are critically ill and immunocompromised and is almost always a sign of pseudomonal sepsis. The characteristic lesions of EG are hemorrhagic pustules or infracted-appearing areas with surrounding erythema that evolve into necrotic ulcers surrounded by erythema.



  • Erythroderma- Most published series reveal that the majority of patients are diagnosed with psoriasis, spongiotic dermatitis, drug reactions or cutaneous T cell lymphoma (CTCL). 



  • Ichthyosis vulgaris -This buildup is a result of your skin's natural shedding process being slowed or inhibited.

Ichthyosis vulgaris is most often caused by a genetic mutation, inherited in an autosomal dominant pattern. That means a child has to inherit only one copy of the affected gene to develop the disease. Children with the inherited form of the disorder usually have normal skin at birth, but develop scaling and roughness during the first few years of life. At times, ichthyosis vulgaris may disappear during the adult years, only to return later.
Ichthyosis not caused by genetic abnormalities, referred to as acquired ichthyosis, is rare. This type usually shows up in adulthood. It's usually associated with other diseases, such as cancer, thyroid disease or chronic renal failure.



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